Heavy Metal Contamination of Water Bodies, Soils and Vegetables in Peri-Urban Areas: A Case Study in Bangaluru

A study was conducted in peri-urban Bangaluru (where city wastewater from four water bodies, viz., Bellandur, Varthur, Byramangala and Nagavara tanks, is being used for cultivation of vegetable crops) to assess heavy metal contamination in water, soil and vegetable samples. Analyses revealed that concentration of cadmium (Cd) and chromium (Cr) in waters from all the tanks exceeded recommended levels of 0.01 and 0.1 mg/l, respectively, while content of lead (Pb) and nickel (Ni) are within safe limits. Concentration of Cd was highest in the water of Bellandur tank (0.039 mg/ l) and of Cr was highest in the water of Byramangala tank (0.311 mg/l). Bellandur and Varthur tanks were found highly contaminated with Cd, Pb and Ni. Mean concentration of heavy metals in soils receiving sewage water from the four tanks ranged from 1.92 to 2.9 mg/kg for Cd, 47.04 to 68.12 mg/kg for Pb, 35.08 to 92.78 mg/kg for Cr and 48.2 to 57.3 mg/kg for Ni. Cd and Pb content were highest in soils around Varthur and Bellandur tanks, while, mean concentration of Cr was highest in soils around Byramangala tank. Similar trends were observed for heavy metal content in vegetables. Among the vegetables studied, leafy vegetables accumulated higher concentration of heavy metals, followed by root vegetables. Cd concentration in all the vegetables grown around Varthur and Bellandur tanks exceeded the safe limit prescribed under Prevention of Food Adulteration Act (PFA 1954). Pb and Ni concentration exceeded safe limits in all the vegetables in all the tank areas studied

A Market Survey of Vegetables in Bangalore for Heavy Metal Contamination in Relation to Human Health

Vegetable samples from one of the main whole sale markets of Bangalore city were collected over two years and analysed for heavy metals such as Cd, Pb, Cr and Ni. Heavy metal content of vegetables ranged from 0.24 to 2.54 mg Cd kg-1, 2.16 to 10.40 mg Pb kg-1, 3.08 to 16.2 mg Cr kg-1 and 1.66 to 11.52 mg Ni kg-1. Leafy vegetables accumulated higher concentration of heavy metals followed by root vegetables. Fruit vegetables accumulated the lowest content of heavy metals. But the heavy metal content of all the vegetables crossed the safe limits permitted for human consumption to a far greater extent except that Cd content of root and fruit vegetables were within the safe levels. Among leafy vegetables, amaranthus and palak accumulated the highest content of all the four heavy metals studied

Environmental Risks Associated with Heavy Metal Contamination in Soil, Water and Plants in Urban and Periurban Agriculture

The India's population living in cities and urban areas has doubled to 27.8% since Independence. Our cities face enormous challenges of environmental pollution and health related problems. City authorities have often been reluctant to accept urban and periurban agriculture because of perceived health risks. Nevertheless, in most cities the world over, periurban agriculture is practiced on a substantial scale, despite prohibitive laws and regulations. Non-degradable pollutants added to the system through anthropogenic activities like heavy metals in air, soil, water and crops bother us more than others as these tend to bio-accumulate. Throughout history, heavy metal contamination has long plagued mankind - undermining intelligence and causing debasing behaviour. Toxicity of some of the heavy metals even leads to deficiency of essential metals like Zn, Cu, etc. in both human and animals. Climate, nutritional status, genetic predisposition, type of work and exposure level influence the intensity of impact on health. Permissible levels prescribed by different organizations differ because of differences in tolerance levels of people of different origins and differences in threat perception of the people. With our current level of knowledge a permanent and foolproof method to stop entry of heavy metals into the food chain is impossible. However, methods are available to reduce intensity of the effects. Alternative land use with crops not directly consumed by human beings and animals offers a better remedy to contain heavy metal entry into food chain. India has a wide ranging set of environmental laws that lay down norms for air, water, soil, wastes, etc. Legislative frame work has been developed in the belief that a policing model is sufficient. It does not go beyond that. Regulatory mechanisms may not be effective in isolated cases but are essential drivers to augment other approaches, by putting a "cap" on the level of degradation that is socially acceptable, as well as creating space for other, cleaner and more acceptable alternatives to be "viable"

A comparative Assessment of Social Safety Net Programs in Andhra Pradesh and Madhya Pradesh: Impact on Smallholder Agriculture and Rural Livelihoods

This paper has presented a comparative assessment of impact of major social safety nets (SSN) in Andhra Pradesh and Madhya Pradesh, by conducting a village based assessment. The study has used the database of selected components of panel household survey data compiled by ICRISAT. This was supplemented by focus group discussions and key informant survey in each of the six villages from AP and MP selected for the assessment: four villages in AP and two villages in MP. The results have suggested that institutionalized government SSN programs like Public Distribution System (PDS), National Old Age Pension Scheme (NOAP), Mid-day Meal (school) programme and subsidies on rural infrastructure (inputs on house, toilets) are widespread across the study villages; and these programs have played a vital role in reducing the economic vulnerability and distress in farming specially of agricultural labour households. In comparison to MP, the rural households in AP have been found relying more on the governmental SSN. Contradictory to the objectives of SSN programs, the underprivileged labour class households were least benefited in the study villages. However, in Madhya Pradesh, labour class households were getting more benefits than the other three classes of farm households. According to the study, the MGNREGS has been able to address the needs of poor and vulnerable households in coping with the economic backwardness through achieving employment and food security, economic sustainability, and increased productivity of labour.The program has also led to enhancing the poor and vulnerable households’ asset base and breaking their indept-cycle

Process Documentation Research and Impact of Community-Driven Development Grants Research in Rural India, Socioeconomics Discussion Paper Series 34

In 2011 ICRISAT gave experimental grants to six dryland villages targeted by the “Village Dynamics Studies in South Asia” (VDSA) project. Two villages were located in Telangana state (undivided Andhra Pradesh) and four in Maharashtra state. A grant of USD 7,000 (Rs. 315,000) was given to each villages to assess the role of local governance and institutions on agricultural performance, and to evaluate development pathways. The community was free to decide where and how to use the grant. Using the Process Documentation Research (PDR) framework, this report documents the activities of the ICRISAT-VDSA project team and the community implementation committee in using the grant, and lessons learned in the process. We also estimated the number of beneficiaries and the economic benefits from the grant. In two villages, the annual economic benefits from the grant were almost equal to the total grant expenditure. In five villages, the cumulative benefits over the last four years exceeded the total value of the grant. Unlike other publically-funded projects, large numbers of households from minority and socially weaker sections also benefited. The results suggest that, given the opportunity, local communities can effectively execute local infrastructure development projects through need-based collective action, while lowering the transaction costs of community action. By involving local community members in planning and implementing projects, the village grant provided benefits to a large number of households and generated substantial economic benefits. The experiment provides useful lessons for scaling-out village grants to other project villages, and for rural development agencies in India and elsewhere

Physio-biochemical responses of polyembryonic mango (Mangifera indica L.) genotypes to varying levels of salinity stress

Mango genotypes that are salinity tolerant can possibly be used as clonal rootstock for sustained production of salinity sensitive commercial mango cultivars in salt affected soils. Present study was carried out to elucidate the effect of salinity stress induced by salts of NaCl+CaCl2 (1:1) at concentrations of 0, 25, 50 and 100 mM on fifteen polyembryonic mango genotypes. The physio-biochemical parameters such as relative water content, chlorophyll content, epicuticular wax content, water potential (Ψ), carbohydrate content, lipid peroxidation, proline accumulation and antioxidant enzymes were determined at each level of salinity in all genotypes. On the basis of these physio-biochemical changes, the study illustrated that the polyembryonic genotypes, Turpentine, Deorakhio, Olour, Bappakkai, Vattam, Nekkare, Kurukkan, Kensington, Muvandan, EC-95862, Manipur, Sabre, Vellaikolamban, Kitchener and Mylepelian were in the decreasing order in response to salinity stress tolerance

Are textbook lungs really normal? A cadaveric study on the anatomical and clinical importance of variations in the major lung fissures, and the incomplete right horizontal fissure.

INTRODUCTION: The lungs have three main fissures: the right oblique fissure (ROF), right horizontal fissure (RHF), and left oblique fissure (LOF). These can be complete, incomplete or absent; quantifying the degree of completeness of these fissures is novel. Standard textbooks often refer to the fissures as complete, but awareness of variation is essential in thoracic surgery. MATERIALS AND METHODS: Fissures in 81 pairs of cadaveric lungs were classified. Oblique fissures were measured from lung hila posteriorly to the lung hila anteriorly; and the RHF measured from the ROF to the anteromedial lung edge. The degree of completeness of fissures was expressed as a percentage of the total projected length were they to be complete. The frequency and location of accessory fissures was noted. RESULTS: LOF were complete in 66/81 (81.5%), incomplete in 13/81 (16.0%) and absent in 2/81 (2.47%); ROF were complete in 52/81 (64.2%), incomplete in 29/81 (35.8%) and never absent; RHF were more variable, complete in 18/81 (22.2%), incomplete in 54/81 (66.7%) and absent in 9/81 (11.1%). LOF and ROF were on average 97.1% and 91.6% complete, respectively, being deficient posteriorly at the lung hila. The RHF on average 69.4% complete, being deficient anteromedially. There were accessory fissures in 10 left and 19 right lungs. CONCLUSIONS: This study provides a projection of the anatomy thoracic surgeons may encounter at operation, in particular the variable RHF. This knowledge is essential for optimal outcomes in both benign and oncological procedures influenced by the fissures

High ALDH Activity Identifies Chemotherapy-Resistant Ewing's Sarcoma Stem Cells That Retain Sensitivity to EWS-FLI1 Inhibition

Cancer stem cells are a chemotherapy-resistant population capable of self-renewal and of regenerating the bulk tumor, thereby causing relapse and patient death. Ewing's sarcoma, the second most common form of bone tumor in adolescents and young adults, follows a clinical pattern consistent with the Cancer Stem Cell model - remission is easily achieved, even for patients with metastatic disease, but relapse remains frequent and is usually fatal.We have isolated a subpopulation of Ewing's sarcoma cells, from both human cell lines and human xenografts grown in immune deficient mice, which express high aldehyde dehydrogenase (ALDH(high)) activity and are enriched for clonogenicity, sphere-formation, and tumor initiation. The ALDH(high) cells are resistant to chemotherapy in vitro, but this can be overcome by the ATP binding cassette transport protein inhibitor, verapamil. Importantly, these cells are not resistant to YK-4-279, a small molecule inhibitor of EWS-FLI1 that is selectively toxic to Ewing's sarcoma cells both in vitro and in vivo.Ewing's sarcoma contains an ALDH(high) stem-like population of chemotherapy-resistant cells that retain sensitivity to EWS-FLI1 inhibition. Inhibiting the EWS-FLI1 oncoprotein may prove to be an effective means of improving patient outcomes by targeting Ewing's sarcoma stem cells that survive standard chemotherapy

Fog computing security: a review of current applications and security solutions

Fog computing is a new paradigm that extends the Cloud platform model by providing computing resources on the edges of a network. It can be described as a cloud-like platform having similar data, computation, storage and application services, but is fundamentally different in that it is decentralized. In addition, Fog systems are capable of processing large amounts of data locally, operate on-premise, are fully portable, and can be installed on heterogeneous hardware. These features make the Fog platform highly suitable for time and location-sensitive applications. For example, Internet of Things (IoT) devices are required to quickly process a large amount of data. This wide range of functionality driven applications intensifies many security issues regarding data, virtualization, segregation, network, malware and monitoring. This paper surveys existing literature on Fog computing applications to identify common security gaps. Similar technologies like Edge computing, Cloudlets and Micro-data centres have also been included to provide a holistic review process. The majority of Fog applications are motivated by the desire for functionality and end-user requirements, while the security aspects are often ignored or considered as an afterthought. This paper also determines the impact of those security issues and possible solutions, providing future security-relevant directions to those responsible for designing, developing, and maintaining Fog systems

Serum Metabolomics Reveals Higher Levels of Polyunsaturated Fatty Acids in Lepromatous Leprosy: Potential Markers for Susceptibility and Pathogenesis

Leprosy is an infectious disease caused by the obligate intracellular bacterium Mycobacterium leprae. M. leprae infects the skin and nerves, leading to disfigurement and nerve damage, with the severity of the disease varying widely. We believe there are multiple factors (genetic, bacterial, nutritional and environmental), which may explain the differences in clinical manifestations of the disease. We studied the metabolites in the serum of infected patients to search for specific molecules that may contribute to variations in the severity of disease seen in leprosy. We found that there were variations in levels of certain lipids in the patients with different bacterial loads. In particular, we found that three polyunsaturated fatty acids (PUFAs) involved in the inhibition of inflammation were more abundant in the serum of patients with higher bacterial loads. However, we do not know whether these PUFAs originated from the host or the bacteria. The variations in the metabolite profile that we observed provide a foundation for future research into the explanations of how leprosy causes disease